R&D Scientist – LC-MS/MS & GC-MS/MS Method Development
We are seeking an experienced R&D Scientist specializing in LC-MS/MS and GC-MS/MS to support the development, optimization, and validation of pesticide testing methods for cannabis and cannabis products.
The primary focus of this role will be the development and implementation of analytical methods for pesticide panels based on European Pharmacopoeia (EP) requirements and Israeli cannabis pesticide requirements. The successful candidate should have strong hands-on experience with triple-quadrupole mass spectrometry and be capable of independently developing methods from initial literature/regulatory review through validation and routine laboratory implementation.
Key Responsibilities
- Develop and optimize pesticide testing methods using LC-MS/MS and GC-MS/MS.
- Review EP, Israeli, and other applicable pesticide regulatory requirements and establish appropriate analyte panels and specifications.
- Develop and optimize sample preparation procedures for cannabis flower, extracts, oils, edibles, and other cannabis matrices.
- Optimize chromatographic conditions, MRM transitions, collision energies, retention times, and instrument parameters.
- Evaluate extraction efficiency, matrix effects, recovery, selectivity, sensitivity, and potential interferences.
- Establish appropriate calibration strategies, internal standards, QC samples, and system suitability requirements.
- Perform method validation including:
- Accuracy/recovery
- Precision
- Specificity/selectivity
- Linearity and calibration range
- LOD and LOQ
- Matrix effects
- Carryover
- Robustness
- Measurement uncertainty, where applicable
- Troubleshoot LC-MS/MS and GC-MS/MS analytical and instrumentation issues.
- Prepare method development reports, validation protocols, validation reports, SOPs, worksheets, and technical documentation.
- Transfer developed methods to routine laboratory analysts and provide training.
- Support implementation of methods within an ISO/IEC 17025 quality system.
- Work with QA and laboratory management to ensure methods meet regulatory and accreditation requirements.
Qualifications
- B.Sc., M.Sc., or Ph.D. in Analytical Chemistry, Chemistry, Pharmaceutical Sciences, or a related scientific discipline.
- Strong hands-on experience with **LC-MS/MS and GC-MS/MS
Pay: $55,000.00-$70,000.00 per year
Benefits:
- Company pension
- Dental care
- Extended health care
- On-site parking
Work Location: In person
