At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Sr. Scientist , Stem Cell Model Engineering
What you will do
Let’s do this. Let’s change the world. In this vital role, you will join the Predictive Biology team as a hands-on scientist focused on building genetically engineered human induced pluripotent stem cell (iPSC) models to support target discovery, target validation, and mechanism-of-action studies. You will troubleshoot complex systems, improve current workflows, and help drive the next wave of innovation in human stem cell model engineering.
Key Responsibilities
- Develop genetically defined iPSC model systems, including reporter, tagged, loss-of-function, disease-relevant, inducible, or otherwise perturbable models.
- Define and interpret fit-for-purpose validation strategies to determine whether engineered models are suitable for downstream biological studies.
- Identify, troubleshoot, and solve technical and biological failure modes, including poor editing outcomes, clonal artifacts, expression instability, differentiation defects, and loss of engineered function.
- Drive innovation by identifying technical gaps, improving workflows, and building new capabilities in engineered human stem cell models.
- Communicate technical risks, timelines, decision points, and model readiness clearly through written and oral presentations.
- Maintain high standards for data integrity, reproducibility, documentation, and experimental rigor.
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a professional with these qualifications.
Basic Qualifications
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PhD in a related discipline with 2+ years of experience
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MSc with 5+ years of experience.
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BSc with 8+ years of experience.
Preferred Qualifications
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PhD with 2+ years of postdoctoral and/or industry experience in stem cell biology, molecular biology, cell engineering, genetics, developmental biology, bioengineering, or a related discipline.
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Demonstrated hands-on experience generating CRISPR edited human iPSC models or other difficult-to-engineer human cellular model systems.
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Strong experimental judgment in genome-engineering strategy, model design, validation requirements, and interpretation of engineered cell model data.
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Practical understanding of common failure modes in engineered iPSC models, including clonal artifacts, unintended genetic changes, expression instability, differentiation issues, and loss of engineered behavior.
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Demonstrated scientific productivity and technical credibility through peer-reviewed publications and patents
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Strong communication and collaboration skills and ability to work effectively as part of a multidisciplinary team.
What you can expect of us
As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.
Amgen is proud to have been recognized as one of LinkedIn Top 25 Companies in Canada for career growth. Click HERE for more details.
The salary range for this position in Canada is $115,503 - $156,269 CAD.
In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
